Abstract Search

ea0034p351 | Steroids | SFEBES2014

High 11β-HSD1 activity is associated with progression to rheumatoid arthritis in patients first presenting with inflammatory arthritis

Nanus Dominika , Filer Andrew D , Yeo Lorraine , Scheel-Toellner Dagmar , Hardy Rowan , Lavery Gareth L , Stewart Paul M , Buckley Christopher D , Cooper Mark S , Raza Karim

Variation in endogenous glucocorticoid (GC) activity during inflammation has been linked to susceptibility to developing rheumatoid arthritis (RA). It has been shown that in patients with RA inflamed synovial tissue can generate active GCs through the expression of the 11β-hydroxysteroid dehydrogenase type 1 enzyme (11β-HSD1), which converts cortisone to cortisol. We examined whether the total body activity of 11β-HSD1 or its expression within synovium was assoc...

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ea0031oc1.1 | Young Endocrinologists prize session | SFEBES2013

TNFα directly regulates in vivo corticosteroid metabolism in inflammatory arthritis

Nanus Dominika E , Filer Andrew , Fisher Benjamin A , Taylor Peter C , Stewart Paul , Buckley Christopher D , McInnes Iain , Cooper Mark S , Raza Karim

Within the synovium of patients with rheumatoid arthritis (RA), synovial fibroblasts generate active corticosteroids through expression of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). In vitro, this enzyme is strongly up-regulated by pro-inflammatory cytokines such as tumour necrosis factor α (TNFα) and IL1β. In this study, we determined the relationship between inflammation and global 11β-HSD1 activity in vivo, in a clini...

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Endocrine Abstracts

High 11β-HSD1 activity is associated with progression to rheumatoid arthritis in patients first presenting with inflammatory arthritis

TNFα directly regulates in vivo corticosteroid metabolism in inflammatory arthritis

BiosciAbstracts